Can Antibiotic Beads Have An Impact In Osteomyelitis Cases?
- Volume 16 - Issue 10 - October 2003
- 18103 reads
- 1 comments
Dr. Yung is a Chief Resident and Dr. Steinberg (shown at right) is an Assistant Professor within the Department of Orthopaedics, Podiatry Division at the University of Texas Health Science Center in San Antonio, Texas.
Editor’s Note: For a related article, see “Can The Osteoset Lead To Better, Cost-Effective Healing?,” on page 70 of the December 2002 issue or check out the archives at www.podiatrytoday.com.
1. Solberg BD, Gutow AP, Baumgaertner MR. Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. J Orthop Trauma 1999 13:102-106.
2. Cho SH, Song HR, Koo KH. Antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis. Bull Hospital Joint Diseases, 1997: 56: 140-144.
3. Isiglar ZU, Demirors H, Akpinar S et al. Two-stage treatment of chronic staphylococcal orthopaedic implant related infection using vancomycin impregnated PMMA space and rifampin containing antibiotics protocol. Bull Hosp Joint Diseases 58: 79-85 1999.
4. Henry SL, Galloway KP. Local antibacterial therapy for the management of orthopedic infections: Pharmacokinetic considerations. Clin Pharmacokinet 29: 36-45 1995.
5. Horowitz SM, Frondoza CG, Lennox DW. Effects of polymethylmetacrylate exposure upon macrophages. J Orthop Res. 6:827-832 1988,
6. Petty W. The effect of methylmethacrylate on bacterial phagocytosis and killing by human polymorphonuclear leukocytes. JBJS 77B: 93-97, 1995.
7. Wilson KJ, Cierny G, Adams KR and Mader JT. Comparative evaluation of diffusion of tobromycin and cefotaxime out of antibiotic-impregnated polymethylmethacrylate beads. J Orthop Res 6: 279-286 1988.
8. Kelly CM, Wilkins RM, Gitelis S, Hartjen C, Watson JT and Kim PT. The use of Surgical Grade Calcium Sulfate as a Bone Graft Substitute. Clinical Orthopaedics and Related Research. 382: 42-50 2001.
9. Pujalte J, Wicklund B, Tsukayama D, et al. Elution of tobramycin from plaster of Paris pellets. Proceedings from the 44th Annual Meeting of the Orthopaedic Research Society, 1998.
10. Richelsoph KC, Petersen DW, Haggard WO, et al. Elution characteristics of tobramycin-impregnated medical grade calcium sulfate hemihydrate. Proceedings from the 44th Annual Meeting of the Orthopaedic Research Society, 1998.
11. Wichelhaus TA, Dingeldein E, Rauschmann M, Sluge S, Dieterich R, Schafer V and Brade V. Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads. Journal of Antimicrobial Chemotherapy. 48: 117-119 2001.)
12. Turner, TM, Urban RM, Gitelis S, Kuo KN, and Andersson GBJ. Radiographic and Histologic Assessment of Calcium Sulfate in Experimental Animal Models and Clinical use as a resorbable Bone-Graft Substitute, a bone-graft expander, and a method for local antibiotic delivery. JBJS 83A Suppl 2 8-18 2001.
13. Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR and Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J. Orthopedic Research. 20: 643-47 2002.
14. McKee MD, Wild LM, Schemitsch EH and Wadell JP. The Use of an Antibiotic-Impregnated Osteoconductive, Bioabsorbable Bone Substitute in the Treatment of Infected Long Bone Defects: Early Results of a Prospective Trial. Journal of Orthopaedic Trauma. 16: 622-627 2002.